mTOR

Technology

The mammalian target of rapamycin, commonly known as mTOR, is a large serine/threonine protein kinase that regulates cell growth, proliferation and survival by impacting on protein synthesis and transcription. Current research indicates that mTOR integrates input from multiple pathways, including insulin signalling, nutrient sensing and growth factors signalling (for example IGF-1 and IGF-2). The inhibition of mTor by rapamycin causes immunosuppression, and more recently clinical studies of a rapamycin analogue have revealed beneficial effects in rheumatoid arthritis. These findings suggest mTor is an attractive drug target not only for the suppression of transplant rejection, but also for inflammatory diseases.

We have formatted a » Kinobeads™ assay for this difficult-to-screen target and have identified hits from our library which are currently being optimised.

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