Zap-70

Technology

Zap-70 (Zeta-associated protein of 70 kilodalton) is a member of the protein tyrosine-kinase class of drug targets. Zap-70 activates Itk and other proteins after T-lymphocytes become stimulated by antigen binding to the T-cell receptor.

The potential of Zap-70 as a target for anti-inflammatory therapies has been known for a long time, but is has proven difficult to develop potent drug-like inhibitors. Using » Kinobeads™, Cellzome has identified a physiologically relevant form of Zap-70 in T-cells, which is accessible to small molecule screening. Our approach has already led to the identification of potent inhibitors of cellular Zap-70 activity.

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