Inflammatory Kinases
Inflammatory diseases often share biological mechanisms, like cytokine release or chemotaxis of immune cells to the site of inflammation. The molecular signalling pathways underlying these cellular responses are relayed and modulated to a large extend by kinases, rendering these enzymes as attractive targets.
One of the key obstacles in kinase drug discovery is the difficulty to obtain selectivity within this large target class. While spectrum-selectivity can be advantageous in cancer drugs, it will most likely not provide for a sufficiently large therapeutic window needed in inflammatory diseases.
» Kinobeads™ helps our drug discovery team identify novel and selective compounds, as potential anti-inflammatory drugs. The targets we are addressing with Kinobeads™ are » PI3Kγ,
» PI3Kδ, » mTor, » Zap-70 and » JAK3 in particular conformations. They represent key mediators in immune receptor signalling and chemotaxis.
« Back