Kinobeads™

" ... the technique as described represents the state of the art for real-world chemical proteomics studies."
Peters E.C., Gray N.S. Chemical proteomics identifies unanticipated targets of clinical kinase inhibitors. ACS Chemical Biology 2, 661-644 (2007).

Nature Biotechnology Kinobeads Cover

Bantscheff, M. et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. NBT 25, 1035-1044 (2007). © Nature Biotechnology

We are applying » Kinobeads™ to all aspects of the drug discovery process, from » library screening to the analysis of drug effects in patients.

Kinobeads™ is a kinase-binding matrix that can be used to measure quantatively the binding interaction of a compound with more than 300 different kinases at the same time. The resulting information can elucidate a compound's mode of action and therefore indicate which diseases it might be used against, or point to potential side effects.

Kinobeads™ can replace or complement the current established methods for screening and selectivity profiling of kinase inhibitors to over- come some of the challenges in kinase drug discovery.

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