Kinobeads™ Profiling

Competition binding experiment with Kinobeads™

Capturing a sub-proteome of drug targets:
Kinobeads™ bind a large number of proteins, primarily kinases but also other enzymes that can bind to ATP or other nucleotides (e.g. helicases or phosphodiesterases). In total, more than 1,000 different proteins are bound by Kinobeads™. With mass spectrometry, the level of the different kinases isolated by Kinobeads™ from any cell or tissue type can be monitored.

Measuring the effect of compounds:
A compound or drug added to a cell or tissue contents before Kinobeads™ will compete for binding of the kinases. This competition is quantified with mass spectrometry and a full quantitative target profile can be determined from a single tissue sample.

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