Pipeline

Project Indication Discovery Preclinical Phase I Phase II
H4 Receptor Asthma, Allergic Rhinitis, Pruritis
PI3K gamma Rheumatoid Arthritis (RA), Lupus
PI3K delta Astma, Rheumatoid Arthritis
mTOR Multiple Sclerosis, RA
Zap-70 Multiple Sclerosis, RA
JAK3 RA, Psoriasis, Transplant Rejection
LRRK2 Parkinson's Disease
GSM Alzheimer's Disease
Novel Targets Alzheimer's Disease
Proprietary projects
Partnered with Johnson & Johnson

Cellzome's proprietary pipeline is focused on inflammatory diseases. » PI3Kγ, » PI3Kδ,
» Zap-70, » mTOR and » JAK3 are all » Kinobeads driven projects, targeting key » kinases in inflammation.

LRRK2 is a large difficult-to-screen kinase which is genetically linked to Parkinson's disease.

In » Alzheimers's Disease, our γ-secretase project and novel targets of the APP pathway
are partnered with Johnson & Johnson.
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